At Evolved.Bio, we’ve taken a groundbreaking leap beyond traditional cell sheet technologies, which were first developed in Japan in the 1990s. Our unique approach, Anchored Cell Sheet Engineering, refines and extends this foundational technique to meet the needs of regenerative medicine.
Traditional cell sheets are created using temperature-responsive surfaces that allow layers of cells to detach without enzymes, preserving crucial cell connections and the extracellular matrix (ECM), key for successful tissue integration. While effective, this method has limitations in cell and ECM maturity and it's difficult to scale.
Our platform enhances this process by cultivating cells on flexible membranes patterned from nano- to micro-scales. This innovative approach eliminates the need for temperature changes or other external stimuli for detachment. Additionally, strategically placed pillars on the membrane serve as anchors, giving us unprecedented control over the shape, mechanical properties, and dimensions of the resulting tissue constructs.
Tissue specific acellular ECM constructs, with composition and microstructures identical to muscle ECM, engage the body's natural healing processes to fully regenerate muscle tissue in the case of VML.
Scaffolds/biomaterials, such as animal derived ECM products, currently being used in clinic result in partial healing and long-lasting chronic inflammation.
Evolved.Bio is brain child of John and Alireza. To learn more about us, check out our LinkedIn page.
Contact: info@itsevolved.com Copyright © 2024 Evolved.Bio - All Rights Reserved.
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